Description

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Parkinson's disease is the second most common neurodegenerative disorder affecting millions of people worldwide. In order to find neuroprotective strategies, the mechanisms of the disease need to be understood, and there have been links made between oxidative damage and Parkinson's disease. This book provides a thorough review of the latest research developments regarding the mechanisms by which oxidative stress and redox signalling mediate Parkinson's disease. It is designed to cover basic knowledge regarding oxidative stress and redox signalling, Parkinson's disease, and neurodegeneration, while also exploring in detail the latest advancement in the research field. Topics covered will include dopamine metabolism, metal homeostasis and DNA-damage. The text will also discuss the current advance in the identification of potential biomarkers for diagnosis and disease progression and the future of antioxidant based therapeutics. Written by recognised experts in the field this book will be a great source of information for postgraduate students and academics, clinicians, toxicologists and risk assessment groups.

About the Author

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Dr Franco is an Assistant Professor of Neuroscience at the Redox Biology Center, University of Nebraska-Lincoln. Prior to this position, he was post-doctoral fellow at the National Institute of Environmental Health Sciences, USA. His research interests include the role of oxidative stress and redox signaling in the regulation of cell death pathways, and in neuronal cell death associated with neurological disorders. He has been awarded the Layman Award and the SIGMA XI Outstanding Young Scientist Award. Dr Doorn is an Associate Professor of Medicinal and Natural Products Chemistry at the University of Iowa, College of Pharmacy. Before this, he was a post-doctoral fellow at the University of Colorado Health Sciences Center, Depts. of Pharmaceutical Sciences and Pharmacology, USA. His postdoctoral work involved studying the role of lipid peroxidation products and protein carbonylation in alcoholic liver disease. Dr Doorn received his Ph.D. from the University of Michigan, School of Public Health, Toxicology Program. Dr Rochet is an associate professor in the Department of Medicinal Chemistry and Molecular Pharmacology (College of Pharmacy) at Purdue University. Before his arrival at Purdue, Dr Rochet received his PhD degree at the University of Alberta in Biochemistry in 1998 and then worked as a post-doctoral fellow studying mechanisms of alpha-synuclein self-assembly in Parkinson's disease in the laboratory of Dr. Peter Lansbury at Harvard Medical School. Dr.Rochet's research group has a long-standing interest in Parkinson's disease.